Replay of large-scale spatio-temporal patterns from waking during subsequent NREM sleep in human cortex.

ABSTRACT: Animal studies support the hypothesis that in slow-wave sleep, replay of waking neocortical activity under hippocampal guidance leads to memory consolidation. However, no intracranial electrophysiological evidence for replay exists in humans. We identified consistent sequences of population firing peaks across widespread cortical regions during complete waking periods. The occurrence of these "Motifs" were compared between sleeps preceding the waking period ("Sleep-Pre") when the Motifs were identified, and those following ("Sleep-Post"). In all subjects, the majority of waking Motifs (most of which were novel) had more matches in Sleep-Post than in Sleep-Pre. In rodents, hippocampal replay occurs during local sharp-wave ripples, and the associated neocortical replay tends to occur during

SUBMITTER: Jiang X 

PROVIDER: S-EPMC5727134 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature