Whole-genome sequencing for an enhanced understanding of genetic variation among South Africans.

ABSTRACT: The Southern African Human Genome Programme is a national initiative that aspires to unlock the unique genetic character of southern African populations for a better understanding of human genetic diversity. In this pilot study the Southern African Human Genome Programme characterizes the genomes of 24 individuals (8 Coloured and 16 black southeastern Bantu-speakers) using deep whole-genome sequencing. A total of ~16 million unique variants are identified. Despite the shallow time depth since divergence between the two main southeastern Bantu-speaking groups (Nguni and Sotho-Tswana), principal component analysis and structure analysis reveal significant (p < 10^-6) differentiation, and F_ST analysis identifies regions with high divergence. The Coloured individuals show

SUBMITTER: Choudhury A 

PROVIDER: S-EPMC5727231 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature