MiR-1 suppresses the proliferation and promotes the apoptosis of esophageal carcinoma cells by targeting Src.

ABSTRACT: Nonreceptor tyrosine kinase c-Src, also known as Src, is a potent oncogene involved in a series of biological processes including cell growth, differentiation, and apoptosis; however, its expression pattern and function in esophageal cancer is poorly addressed. In this study, abnormal overexpression of Src protein was observed in esophageal cancer tissues, which fuelled the speculation that microRNA-mediated posttranscriptional regulatory mechanism might be involved. Bioinformatic analyses were applied to identify miRNAs that could potentially target Src. miR-1 was predicted and further validated as a direct repressor of Src. Moreover, we manipulated knockdown and overexpression experiment on TE-1 and TE-10 cells to demonstrate miR-1 suppressed proliferation and promoted apoptosis in esoph

SUBMITTER: Liao Z 

PROVIDER: S-EPMC5727306 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature