Toenail mineral concentration and risk of esophageal squamous cell carcinoma, results from the Golestan Cohort Study.

ABSTRACT: Studies conducted in China linked selenium deficiency to higher risk of esophageal squamous cell carcinoma (ESCC), but this has not been widely tested outside that selenium-deficient region. The aim of this study was to investigate the association between selenium and other mineral concentrations in toenails and risk of ESCC in a region with high incidence rates. In this nested case-control study, we identified 222 cases of ESCC from the Golestan Cohort Study, Iran, which has followed up 50,045 participants since enrollment (2004-2008). We randomly selected one control for each case matched by age and sex, using incidence density sampling. We used toenail samples collected at baseline to measure the concentration of selenium, zinc, chromium, mercury, and scandium using instrumental neutron

SUBMITTER: Hashemian M 

PROVIDER: S-EPMC5727321 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature