In vivo metabolic imaging of Traumatic Brain Injury.

ABSTRACT: Complex alterations in cerebral energetic metabolism arise after traumatic brain injury (TBI). To date, methods allowing for metabolic evaluation are highly invasive, limiting our understanding of metabolic impairments associated with TBI pathogenesis. We investigated whether ¹³C MRSI of hyperpolarized (HP) [1-¹³C] pyruvate, a non-invasive metabolic imaging method, could detect metabolic changes in controlled cortical injury (CCI) mice (n = 57). Our results show that HP [1-¹³C] lactate-to-pyruvate ratios were increased in the injured cortex at acute (12/24 hours) and sub-acute (7 days) time points after injury, in line with decreased pyruvate dehydrogenase (PDH) activity, suggesting impairment of the oxidative phosphorylation pathway. We then used the colon

SUBMITTER: Guglielmetti C 

PROVIDER: S-EPMC5727520 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature