Evaluating the associations between human circadian rhythms and dysregulated genes in liver cancer cells.

ABSTRACT: Network analysis is a useful approach in cancer biology as it provides information regarding the genes and proteins. In our previous study, a network analysis was performed on dysregulated genes in HepG2 cells, a hepatoblastoma cell line that lacks the viral infection, compared with normal hepatocytes, identifying the presence of 26 HUB genes. The present study aimed to identify whether these previously identified HUB genes participate in the network that controls the human circadian rhythms. The results of the present study demonstrated that 20/26 HUB genes were associated with the metabolic processes that control human circadian rhythms, which supports the hypothesis that a number of cancer types are dependent from circadian cycles. In addition, it was revealed that the CLOCK circadian r

SUBMITTER: Polo A 

PROVIDER: S-EPMC5727601 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature