Exome sequencing of multiple-sclerosis patients and their unaffected first-degree relatives.

ABSTRACT:

Objectives

The understanding of complex multifactorial diseases requires the availability of a variety of data for a large-number of affected individuals. In this data note here we provide whole exome sequencing data from a set of non-familiar multiple-sclerosis (MS) patients as well as their unaffected first-degree relatives. This data might help the identification of genomic alterations, including single nucleotide polymorphisms, de novo variations and structural genomic variations, such as copy-number alterations that may impact this disease.

Data description

This dataset comprises the full exome of 28 Brazilian subjects grouped in eight distinct families, consisting of four complete trios (mother-patient-father) plus another four complete trios with one added unaffected

SUBMITTER: Garcia-Rosa S 

PROVIDER: S-EPMC5727932 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature