Cdc42 is required in a genetically distinct subset of cardiac cells during Drosophila dorsal vessel closure.

ABSTRACT: The embryonic heart tube is formed by the migration and subsequent midline convergence of two bilateral heart fields. In Drosophila the heart fields are organized into two rows of cardioblasts (CBs). While morphogenesis of the dorsal ectoderm, which lies directly above the Drosophila dorsal vessel (DV), has been extensively characterized, the migration and concomitant fundamental factors facilitating DV formation remain poorly understood. Here we provide evidence that DV closure occurs at multiple independent points along the A-P axis of the embryo in a "buttoning" pattern, divergent from the zippering mechanism observed in the overlying epidermis during dorsal closure. Moreover, we demonstrate that a genetically distinct subset of CBs is programmed to make initial contact with the opposin

SUBMITTER: Swope D 

PROVIDER: S-EPMC5728115 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature