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Novel SF3B1 in-frame deletions result in aberrant RNA splicing in CLL patients.

ABSTRACT: We identify and characterize novel SF3B1 in-frame deletions in chronic lymphocytic leukemia.These deletions are functionally similar to well-known SF3B1 hotspot mutations and are sensitive to splicing modulation.

SUBMITTER: Agrawal AA 

PROVIDER: S-EPMC5728324 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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We identify and characterize novel <i>SF3B1</i> in-frame deletions in chronic lymphocytic leukemia.These deletions are functionally similar to well-known <i>SF3B1</i> hotspot mutations and are sensitive to splicing modulation. ...[more]

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