Genetic association with B-cell acute lymphoblastic leukemia in allogeneic transplant patients differs by age and sex.

ABSTRACT: The incidence and mortality rates of B-cell acute lymphoblastic leukemia (B-ALL) differ by age and sex. To determine if inherited genetic susceptibility contributes to these differences we performed 2 genome-wide association studies (GWAS) by age, sex, and subtype and subsequent meta-analyses. The GWAS included 446 B-ALL cases, and 3027 healthy unrelated blood and marrow transplant (BMT) donors as controls from the Determining the Influence of Susceptibility Conveying Variants Related to One-Year Mortality after BMT (DISCOVeRY-BMT) study. We identified 1 novel variant, rs189434316, significantly associated with odds of normal cytogenetic B-ALL (odds ratio from meta-analysis [OR_meta] = 3.7; 95% confidence interval [CI], 2.5, 6.2; P value from meta-analysis [P_me

SUBMITTER: Clay-Gilmour AI 

PROVIDER: S-EPMC5728332 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature