Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets.

ABSTRACT: Megakaryocytes (MKs) are bone marrow-derived cells that are primarily responsible for generating platelets for the maintenance of hemostasis. Although MK can variably express major histocompatibility complex (MHC) class I and II molecules during their differentiation, little is known whether they can elicit nonhemostatic immune functions such as T-cell activation. Here, we demonstrate that mature CD34^- MHC class II^- CD41⁺ MKs can endocytose exogenous ovalbumin (OVA) and proteolytically generate its immunogenic peptide ligand, which is crosspresented on their surface in association with MHC class I molecules. This crosspresentation triggered in vitro and in vivo OVA-specific CD8⁺ T-cell activation and proliferation. In addition, the OVA-MHC class

SUBMITTER: Zufferey A 

PROVIDER: S-EPMC5728336 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature