Randomized phase 2 trial of regadenoson for treatment of acute vaso-occlusive crises in sickle cell disease.

ABSTRACT: Adenosine A_2A receptor (A_2AR) agonists have been shown to decrease tissue inflammation induced by hypoxia/reoxygenation in mice with sickle cell disease (SCD). The key mediator of the A_2AR agonist's anti-inflammatory effects is a minor lymphocyte subset, invariant natural killer T (iNKT) cells. We tested the hypothesis that administration of an A_2AR agonist in patients with SCD would decrease iNKT cell activation and dampen the severity of vaso-occlusive (VO) crises. In a phase 2, randomized, placebo-controlled trial, we administered a 48-hour infusion of the A_2AR agonist regadenoson (1.44 μg/kg per hour) to patients with SCD during VO crises to produce a plasma concentration of ∼5 nM, a concentration known from prior studies to suppre

SUBMITTER: Field JJ 

PROVIDER: S-EPMC5728341 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature