A functional DC cross talk promotes human ILC homeostasis in humanized mice.

ABSTRACT: Humanized mice harboring human hematopoietic systems offer a valuable small-animal model to assess human immune responses to infection, inflammation, and cancer. Human immune system (HIS) mice develop a broad repertoire of antigen receptor bearing B and T cells that can participate in adaptive immune responses after immunization. In contrast, analysis of innate immune components, including innate lymphoid cells (ILCs) and natural killer (NK) cells, is limited in current HIS mouse models, partly because of the poor development of these rare lymphoid subsets. Here we show that novel dendritic cell (DC)-boosted BALB/c Rag2^-/-Il2rg^-/-Sirpa^NODFlk2^-/- (BRGSF) HIS mice harbor abundant NK cells and tissue-resident ILC subsets

SUBMITTER: Lopez-Lastra S 

PROVIDER: S-EPMC5728352 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature