MLL-AF9 leukemias are sensitive to PARP1 inhibitors combined with cytotoxic drugs.
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ABSTRACT:
SUBMITTER: Maifrede S
PROVIDER: S-EPMC5728460 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Publications
MLL-AF9 leukemias are sensitive to PARP1 inhibitors combined with cytotoxic drugs.
Maifrede Silvia S Martinez Esteban E Nieborowska-Skorska Margaret M Di Marcantonio Daniela D Hulse Michael M Le Bac Viet BV Zhao Huaqing H Piwocka Katarzyna K Tempera Italo I Sykes Stephen M SM Skorski Tomasz T
Blood advances 20170809 19
PARP1 is required for the maintenance of MLL-AF9 leukemias.PARP1 inhibitors enhance the therapeutic effect of cytotoxic drugs against MLL-AF9 leukemias. ...[more]
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