Site-selective oxidation, amination and epimerization reactions of complex polyols enabled by transfer hydrogenation.

ABSTRACT: Polyoxygenated hydrocarbons that bear one or more hydroxyl groups comprise a large set of natural and synthetic compounds, often with potent biological activity. In synthetic chemistry, alcohols are important precursors to carbonyl groups, which then can be converted into a wide range of oxygen- or nitrogen-based functionality. Therefore, the selective conversion of a single hydroxyl group in natural products into a ketone would enable the selective introduction of unnatural functionality. However, the methods known to convert a simple alcohol, or even an alcohol in a molecule that contains multiple protected functional groups, are not suitable for selective reactions of complex polyol structures. We present a new ruthenium catalyst with a unique efficacy for the selective oxidation of a s

SUBMITTER: Hill CK 

PROVIDER: S-EPMC5728688 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature