Genetic Deletion of NADPH Oxidase 1 Rescues Microvascular Function in Mice With Metabolic Disease.

ABSTRACT:

Rationale

Early vascular changes in metabolic disease that precipitate the development of cardiovascular complications are largely driven by reactive oxygen species accumulation, yet the extent to which excess reactive oxygen species derive from specific NADPH oxidase isoforms remains ill defined.

Objective

Identify the role of Nox1 in the development of microvascular dysfunction in metabolic disease.

Methods and results

Four genotypes were generated by breeding Nox1 knockout mice with db/db mice: lean (H_dbW_nox1), lean Nox1 knockout (H_dbK_nox1), obese (K_dbW_nox1), and obese KK (K_dbK_nox1). The degree of adiposity, insulin resistance, and dyslipidemia in KW mice was not influenc

SUBMITTER: Thompson JA 

PROVIDER: S-EPMC5729041 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature