Risk of Fracture in Women with Sarcopenia, Low Bone Mass, or Both.

ABSTRACT:

Objectives

To determine whether women with sarcopenia and low bone mineral density (BMD) are at greater risk of clinical fractures than those with sarcopenia or low BMD alone.

Design

Women's Health Initiative (WHI) Observational and Clinical trials.

Setting

Three U.S. clinical centers (Pittsburgh, PA; Birmingham, AL; Phoenix/Tucson, AZ).

Participants

Women (mean age 63.3 ± 0.07) with BMD measurements (N = 10,937).

Measurements

Sarcopenia was defined as appendicular lean mass values corrected for height and fat mass. Low BMD was defined as a femoral neck T-score less than -1.0 based on the Third National Health and Nutrition Examination Survey reference database for white women. Cox proportional hazards analysis was used to calculate hazard ratios (HRs) a

SUBMITTER: Harris R 

PROVIDER: S-EPMC5729083 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature