Network-based brain stimulation selectively impairs spatial retrieval.

ABSTRACT:

Background

Direct brain stimulation via electrodes implanted for intracranial electroencephalography (iEEG) permits the modulation of endogenous electrical signals with significantly greater spatial and temporal specificity than non-invasive approaches. It also allows for the stimulation of deep brain structures important to memory, such as the hippocampus, that are difficult, if not impossible, to target non-invasively. Direct stimulation studies of these deep memory structures, though, have produced mixed results, with some reporting improvement, some impairment, and others, no consistent changes.

Objective/hypothesis

We hypothesize that to modulate cognitive function using brain stimulation, it is essential to modulate connected nodes comprising a network, rather than jus

SUBMITTER: Kim K 

PROVIDER: S-EPMC5729089 | biostudies-literature | 2018 Jan - Feb

REPOSITORIES: biostudies-literature