Antipsychotics and the Risk of Aspiration Pneumonia in Individuals Hospitalized for Nonpsychiatric Conditions: A Cohort Study.

ABSTRACT:

Background/objectives

Off-label use of antipsychotics is common in hospitals, most often for delirium management. Antipsychotics have been associated with aspiration pneumonia in community and nursing home settings, but the association in hospitalized individuals is unexplored. We aimed to investigate the association between antipsychotic exposure and aspiration pneumonia during hospitalization.

Design

Retrospective cohort study.

Setting

Large academic medical center.

Participants

All adult hospitalizations between January 2007 and July 2013. We excluded outside hospital transfers, hospitalizations shorter than 48 hours, and psychiatric hospitalizations.

Measurements

Antipsychotic use defined as any pharmacy charge for an antipsychotic medication. Aspira

SUBMITTER: Herzig SJ 

PROVIDER: S-EPMC5729090 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature