Cognitive Trajectory Changes Over 20 Years Before Dementia Diagnosis: A Large Cohort Study.

ABSTRACT:

Background/objectives

Longitudinal studies have shown an increase in cognitive decline many years before clinical diagnosis of dementia. We sought to estimate changes, relative to "normal" aging, in the trajectory of scores on a global cognitive function test-the Cognitive Abilities Screening Instrument (CASI).

Design

A prospective cohort study.

Setting

Community-dwelling members of a U.S. health maintenance organization.

Participants

Individuals aged 65 and older who had no dementia diagnosis at baseline and had at least two visits with valid CASI test score (N = 4,315).

Measurements

Average longitudinal trajectories, including changes in trajectory before clinical diagnosis in those who would be diagnosed with dementia, were estimated for CASI item res

SUBMITTER: Li G 

PROVIDER: S-EPMC5729097 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature