Genotype-outcome correlations in pediatric AML: the impact of a monosomal karyotype in trial AML-BFM 2004.

ABSTRACT: We conducted a cytogenetic analysis of 642 children with de novo acute myeloid leukemia (AML) treated on the AML-Berlin-Frankfurt-Münster (BFM) 04 protocol to determine the prognostic value of specific chromosomal aberrations including monosomal (MK⁺), complex (CK⁺) and hypodiploid (HK⁺) karyotypes, individually and in combination. Multivariate regression analysis identified in particular MK⁺ (n=22) as a new independent risk factor for poor event-free survival (EFS 23±9% vs 53±2% for all other patients, P=0.0003), even after exclusion of four patients with monosomy 7 (EFS 28±11%, P=0.0081). CK⁺ patients without MK had a better prognosis (n=47, EFS 47±8%, P=0.46) than those with MK⁺ (n=12, EFS 25±13%, P=0.024). HK⁺

SUBMITTER: Rasche M 

PROVIDER: S-EPMC5729330 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature