Loss of Myosin Vb in colorectal cancer is a strong prognostic factor for disease recurrence.

ABSTRACT:

Background

Selecting the most beneficial treatment regimens for colorectal cancer (CRC) patients remains challenging due to a lack of prognostic markers. Members of the Myosin family, proteins recognised to have a major role in trafficking and polarisation of cells, have recently been reported to be closely associated with several types of cancer and might thus serve as potential prognostic markers in the context of CRC.

Methods

We used a previously established meta-analysis of publicly available gene expression data to analyse the expression of different members of the Myosin V family, namely MYO5A, 5B, and 5C, in CRC. Using laser-microdissected material as well as tissue microarrays from paired human CRC samples, we validated both RNA and protein expression of Myosin Vb (M

SUBMITTER: Letellier E 

PROVIDER: S-EPMC5729446 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature