Preliminary evidence supports circulating microRNAs as prognostic biomarkers for type 2 diabetes.

ABSTRACT:

Background

Circulating microRNAs are emerging as potential prognostic biomarkers for the development of type 2 diabetes. However, microRNAs are also associated with complications from impaired glucose metabolism (e.g. endothelial cell function). Prior studies have not evaluated for associations between trajectories of circulating microRNAs with trajectories of fasting blood glucose over time and the responses to behavioral interventions to reduce risk. This study performed longitudinal assessment of microRNAs and fasting blood glucose and identified relationships between microRNAs and behavioral risk reduction interventions.

Methods

MicroRNAs (n = 353) were measured in subsets (n = 10, n = 8) of participants from previously completed clinical trials that studied behavioral r

SUBMITTER: Flowers E 

PROVIDER: S-EPMC5729496 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature