A Key Role for Neurotensin in Chronic-Stress-Induced Anxiety-Like Behavior in Rats.

ABSTRACT: Chronic stress is a major cause of anxiety disorders that can be reliably modeled preclinically, providing insight into alternative therapeutic targets for this mental health illness. Neuropeptides have been targeted in the past to no avail possibly due to our lack of understanding of their role in pathological models. In this study we use a rat model of chronic stress-induced anxiety-like behaviors and hypothesized that neuropeptidergic modulation of synaptic transmission would be altered in the bed nucleus of the stria terminalis (BNST), a brain region suspected to contribute to anxiety disorders. We use brain slice neurophysiology and behavioral pharmacology to compare the role of locally released endogenous neuropeptides on synaptic transmission in the oval (ov) BNST of non-stressed (N

SUBMITTER: Normandeau CP 

PROVIDER: S-EPMC5729557 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature