Tuberculous Meningitis in Children and Adults: New Insights for an Ancient Foe.

ABSTRACT:

Purpose of review

Tuberculous meningitis is the most devastating manifestation of infection with Mycobacterium tuberculosis and represents a medical emergency. Approximately one half of tuberculous meningitis patients die or suffer severe neurologic disability. The goal of this review will be to review the pathogenic, clinical, and radiologic features of tuberculous meningitis and to highlight recent advancements in translational and clinical science.

Recent findings

Pharmacologic therapy includes combination anti-tuberculosis drug regimens and adjunctive corticosteroids. It is becoming clear that a successful treatment outcome depends on an immune response that is neither too weak nor overly robust, and genetic determinants of this immune response may identify which patient

SUBMITTER: Mezochow A 

PROVIDER: S-EPMC5729589 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature