Comparative transcriptomics of 5 high-altitude vertebrates and their low-altitude relatives.

ABSTRACT:

Background

Species living at high altitude are subject to strong selective pressures due to inhospitable environments (e.g., hypoxia, low temperature, high solar radiation, and lack of biological production), making these species valuable models for comparative analyses of local adaptation. Studies that have examined high-altitude adaptation have identified a vast array of rapidly evolving genes that characterize the dramatic phenotypic changes in high-altitude animals. However, how high-altitude environment shapes gene expression programs remains largely unknown.

Findings

We generated a total of 910 Gb of high-quality RNA-seq data for 180 samples derived from 6 tissues of 5 agriculturally important high-altitude vertebrates (Tibetan chicken, Tibetan pig, Tibetan sheep, Tibe

SUBMITTER: Tang Q 

PROVIDER: S-EPMC5729692 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature