Chronic Opioid Therapy Modifies QST Changes After Ketamine Infusion in Chronic Pain Patients.

ABSTRACT: The long-term effects of opioids on sensitization processes are believed to be mediated through the N-methyl-D-aspartate receptor. Quantitative sensory testing (QST) changes observed after a ketamine infusion have been previously described but the effect that chronic opioids will have is not known. The results of this prospective randomized factorial trial compared the thermal QST changes observed after a .05 mg/kg ketamine infusion or a saline placebo in chronic pain subjects who were either opioid-naive or were chronically using opioids for chronic noncancer pain are presented. No baseline QST differences were noted between the 4 groups at baseline. Comparison of changes preinfusion with postinfusion QST measurements resulted in decreased average change in temporal summation response bet

SUBMITTER: Maher DP 

PROVIDER: S-EPMC5729746 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature