Effects of asenapine on agitation and hostility in adults with acute manic or mixed episodes associated with bipolar I disorder.

ABSTRACT:

Background

Bipolar disorder is associated with an increased risk of aggression. However, effective management of hostility and/or agitation symptoms may prevent patients from becoming violent. This analysis investigated the efficacy of the antipsychotic asenapine on hostility and agitation in patients with bipolar I disorder.

Methods

Data were pooled from three randomized, double-blind, placebo-controlled, Phase III trials of asenapine in adults with manic or mixed episodes of bipolar I disorder (NCT00159744, NCT00159796, and NCT00764478). Post hoc analyses assessed the changes from baseline to day 21 on the Young Mania Rating Scale (YMRS) and the Positive and Negative Syndrome Scale (PANSS) hostility-related item scores in asenapine- or placebo-treated patients with at leas

SUBMITTER: Citrome L 

PROVIDER: S-EPMC5729826 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature