Gene Expression as a Dosimeter in Irradiated Drosophila melanogaster.

ABSTRACT: Biological indicators would be of use in radiation dosimetry in situations where an exposed person is not wearing a dosimeter, or when physical dosimeters are insufficient to estimate the risk caused by the radiation exposure. In this work, we investigate the use of gene expression as a dosimeter. Gene expression analysis was done on 15,222 genes of Drosophila melanogaster (fruit flies) at days 2, 10, and 20 postirradiation, with X-ray exposures of 10, 1000, 5000, 10,000, and 20,000 roentgens. Several genes were identified, which could serve as a biodosimeter in an irradiated D. melanogaster model. Many of these genes have human homologues. Six genes showed a linear response (R² > 0.9) with dose at all time points. One of these genes, inverted repeat-binding protein, is a known

SUBMITTER: Shrestha S 

PROVIDER: S-EPMC5729855 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature