M⁶A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways.

ABSTRACT: N⁶-methyladenosine (m⁶A) is the most common and abundant messenger RNA modification, modulated by 'writers', 'erasers' and 'readers' of this mark. In vitro data have shown that m⁶A influences all fundamental aspects of mRNA metabolism, mainly mRNA stability, to determine stem cell fates. However, its in vivo physiological function in mammals and adult mammalian cells is still unknown. Here we show that the deletion of m⁶A 'writer' protein METTL3 in mouse T cells disrupts T cell homeostasis and differentiation. In a lymphopaenic mouse adoptive transfer model, naive Mettl3-deficient T cells failed to undergo homeostatic expansion and remained in the naive state for up to 12 weeks, thereby preventing colitis. Consistent with these observations, the

SUBMITTER: Li HB 

PROVIDER: S-EPMC5729908 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature