Selecting children with suspected inflammatory bowel disease for endoscopy with the calgranulin C or calprotectin stool test: protocol of the CACATU study.

ABSTRACT:

Introduction

The introduction of the faecal calprotectin (FC) test to screen children with chronic gastrointestinal complaints has helped the clinician to decide whether or not to subject the patient to endoscopy. In spite of this, a considerable number of patients without inflammatory bowel disease (IBD) is still scoped. Faecal calgranulin C (S100A12) is a marker of intestinal inflammation that is potentially more specific for IBD than FC, as it is exclusively released by activated granulocytes.

Objective

To determine whether the specificity of S100A12 is superior to the specificity of FC without sacrificing sensitivity in patients with suspected IBD.

Methods

An international prospective cohort of children with suspected IBD will be screened with the existing FC stoo

SUBMITTER: Heida A 

PROVIDER: S-EPMC5730001 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature