Dataset Information

The impact of oral Polypodium leucotomos extract on ultraviolet B response: A human clinical study.

ABSTRACT:

Background

There is a rationale for adding systemic photoprotective agents to the current photoprotection regimen.

Objective

This study was designed to objectively evaluate the molecular and photobiologic effects of oral administration of Polypodium leucotomos extract (PLE).

Methods

In all, 22 subjects with Fitzpatrick skin phototype I to III were enrolled. On day 1, subjects were irradiated with visible light, ultraviolet (UV) A1, and UVB (using 308-nm excimer laser). Evaluation was done immediately and 24 hours after irradiation. On days 3 and 4, irradiation and evaluation process was repeated after ingestion of PLE.

Results

Clinical assessments and colorimetry data showed a decrease in UVB-induced changes in 17 of 22 subjects post-PLE administration; histology findings demonstrated such a decrease in all 22 subjects.

Limitations

Only 2 doses of PLE were given. Furthermore, subjects with skin phototypes I to III only were studied.

Conclusion

The results suggest that PLE can potentially be used as an adjunctive agent to lessen the negative photobiologic effects of UVB.

SUBMITTER: Kohli I

PROVIDER: S-EPMC5730054 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Publications

The impact of oral Polypodium leucotomos extract on ultraviolet B response: A human clinical study.

Kohli Indermeet I Shafi Rubina R Isedeh Prescilia P Griffith James L JL Al-Jamal Mohammed S MS Silpa-Archa Narumol N Jackson Bradford B Athar Mohammed M Kollias Nikiforos N Elmets Craig A CA Lim Henry W HW Hamzavi Iltefat H IH

Journal of the American Academy of Dermatology 20170322 1

<h4>Background</h4>There is a rationale for adding systemic photoprotective agents to the current photoprotection regimen.<h4>Objective</h4>This study was designed to objectively evaluate the molecular and photobiologic effects of oral administration of Polypodium leucotomos extract (PLE).<h4>Methods</h4>In all, 22 subjects with Fitzpatrick skin phototype I to III were enrolled. On day 1, subjects were irradiated with visible light, ultraviolet (UV) A1, and UVB (using 308-nm excimer laser). Eval ...[more]

PMID: 28341348

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Project description:Introduction: Oral cancer refers to malignant tumors, of which 90% are squamous cell carcinomas (OSCCs). These malignancies exhibit rapid progression, poor prognosis, and often mutilating therapeutical approaches. The determination of a prophylactic and/or therapeutic antitumor role of the polyphenolic extract Polypodium leucotomos(PL) would be relevant in developing new tools for prevention and treatment. Methods: We aimed to determine the antitumor effect of PL by treating OSCC cell lines with PL metabolites and evaluating its action during OSCC progression in vivo. Results: PL treatment successfully impaired cell cycling and proliferation, migration, and invasion, enhanced apoptosis, and modulated macrophage polarization associated with the tumoral immune-inflammatory response of tongue cancer cell lines (TSCC). PL treatment significantly decreased the expression of MMP1 (p < 0.01) and MMP2 (p < 0.001), and increased the expression of TIMP1 (p < 0.001) and TIMP2 (p < 0.0001) in these cells. The mesenchymal-epithelial transition phenotype was promoted in cells treated with PL, through upregulation of E-CAD (p < 0.001) and reduction of N-CAD (p < 0.05). PL restrained OSCC progression in vivo by inhibiting tumor volume growth and decreasing the number of severe dysplasia lesions and squamous cell carcinomas. Ki-67 was significantly higher expressed in tongue tissues of animals not treated with PL(p < 0.05), and a notable reduction in Bcl2 (p < 0.05) and Pcna (p < 0.05) cell proliferation-associated genes was found in dysplastic lesions and TSCCs of PL-treated mice. Finally, N-cad(Cdh2), Vim, and Twist were significantly reduced in tongue tissues treated with PL. Conclusion: PL significantly decreased OSCC carcinogenic processes in vitro and inhibited tumor progression in vivo. PL also appears to contribute to the modulation of immune-inflammatory oral tumor-associated responses. Taken together, these results suggest that PL plays an important antitumor role in processes associated with oral carcinogenesis and may be a potential phytotherapeutic target for the prevention and/or adjuvant treatment of TSCCs.

Dataset Information

The impact of oral Polypodium leucotomos extract on ultraviolet B response: A human clinical study.

Background

Objective

Methods

Results

Limitations

Conclusion

Publications

The impact of oral Polypodium leucotomos extract on ultraviolet B response: A human clinical study.

Similar Datasets

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