The Effects of Population-based Prostate-specific Antigen Screening Beginning at Age 40.

ABSTRACT:

Objective

To evaluate population-based prostate cancer (CaP) testing of men in their 40s, given the paucity of prospective data evaluating the consequences of prostate-specific antigen (PSA) testing in younger men for CaP.

Materials and methods

A total of 1052 men in their 40s were followed longitudinally for prostate outcomes, from 1990 to 2010. A random subset of 268 men was selected to undergo biennial CaP testing including PSA testing, transrectal ultrasound, and a digital rectal examination. A representative population of 609 men with a subset of 159 men who also began CaP testing in their 50s was also evaluated as a comparison group. Risk of prostate biopsy (PBx), CaP, or death from CaP was compared between CaP-tested and the routine-care population cohort.

Results<

SUBMITTER: Weight CJ 

PROVIDER: S-EPMC5730083 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature