PamR, a new MarR-like regulator affecting prophages and metabolic genes expression in Bacillus subtilis.

ABSTRACT: B. subtilis adapts to changing environments by reprogramming its genetic expression through a variety of transcriptional regulators from the global transition state regulators that allow a complete resetting of the cell genetic expression, to stress specific regulators controlling only a limited number of key genes required for optimal adaptation. Among them, MarR-type transcriptional regulators are known to respond to a variety of stresses including antibiotics or oxidative stress, and to control catabolic or virulence gene expression. Here we report the characterization of the ydcFGH operon of B. subtilis, containing a putative MarR-type transcriptional regulator. Using a combination of molecular genetics and high-throughput approaches, we show that this regulator, renamed PamR, controls

SUBMITTER: De San Eustaquio-Campillo A 

PROVIDER: S-EPMC5730154 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature