Impact of maternal high fat diet on hypothalamic transcriptome in neonatal Sprague Dawley rats.

ABSTRACT: Maternal consumption of a high fat diet during early development has been shown to impact the formation of hypothalamic neurocircuitry, thereby contributing to imbalances in appetite and energy homeostasis and increasing the risk of obesity in subsequent generations. Early in postnatal life, the neuronal projections responsible for energy homeostasis develop in response to appetite-related peptides such as leptin. To date, no study characterises the genome-wide transcriptional changes that occur in response to exposure to high fat diet during this critical window. We explored the effects of maternal high fat diet consumption on hypothalamic gene expression in Sprague Dawley rat offspring at postnatal day 10. RNA-sequencing enabled discovery of differentially expressed genes between offspri

SUBMITTER: Barrand S 

PROVIDER: S-EPMC5730210 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature