Whole-genome single nucleotide variant distribution on genomic regions and its relationship to major depression.

ABSTRACT: Recent advances in DNA technologies have provided unprecedented opportunities for biological and medical research. In contrast to current popular genotyping platforms which identify specific variations, whole-genome sequencing (WGS) allows for the detection of all private mutations within an individual. Major depressive disorder (MDD) is a chronic condition with enormous medical, social and economic impacts. Genetic analysis, by identifying risk variants and thereby increasing our understanding of how MDD arises, could lead to improved prevention and the development of new and more effective treatments. Here we investigated the distributions of whole-genome single nucleotide variants (SNVs) on 12 different genomic regions for 25 human subjects using the symmetrised Kullback-Leibler diverge

SUBMITTER: Yu C 

PROVIDER: S-EPMC5730269 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature