A bidirectional association between the gut microbiota and CNS disease in a biphasic murine model of multiple sclerosis.

ABSTRACT: The gut microbiome plays an important role in the development of inflammatory disease as shown using experimental models of central nervous system (CNS) demyelination. Gut microbes influence the response of regulatory immune cell populations in the gut-associated lymphoid tissue (GALT), which drive protection in acute and chronic experimental autoimmune encephalomyelitis (EAE). Recent observations suggest that communication between the host and the gut microbiome is bidirectional. We hypothesized that the gut microbiota differs between the acute inflammatory and chronic progressive stages of a murine model of secondary-progressive multiple sclerosis (SP-MS). This non-obese diabetic (NOD) model of EAE develops a biphasic pattern of disease that more closely resembles the human condition whe

SUBMITTER: Colpitts SL 

PROVIDER: S-EPMC5730387 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature