Multi-platform 'Omics Analysis of Human Ebola Virus Disease Pathogenesis.

ABSTRACT: The pathogenesis of human Ebola virus disease (EVD) is complex. EVD is characterized by high levels of virus replication and dissemination, dysregulated immune responses, extensive virus- and host-mediated tissue damage, and disordered coagulation. To clarify how host responses contribute to EVD pathophysiology, we performed multi-platform 'omics analysis of peripheral blood mononuclear cells and plasma from EVD patients. Our results indicate that EVD molecular signatures overlap with those of sepsis, imply that pancreatic enzymes contribute to tissue damage in fatal EVD, and suggest that Ebola virus infection may induce aberrant neutrophils whose activity could explain hallmarks of fatal EVD. Moreover, integrated biomarker prediction identified putative biomarkers from different data plat

SUBMITTER: Eisfeld AJ 

PROVIDER: S-EPMC5730472 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature