Cerebrovascular Reactivity and Vascular Activation in Postmenopausal Women With Histories of Preeclampsia.

ABSTRACT: Cerebrovascular reactivity (CVR) is reduced in patients with cognitive decline. Women with a history of preeclampsia are at increased risk for cognitive decline. This study examined an association between pregnancy history and CVR using a subgroup of 40 age- and parity-matched pairs of women having histories of preeclampsia (n=27) or normotensive pregnancy (n=29) and the association of activated blood elements with CVR. Middle cerebral artery velocity was measured by Doppler ultrasound before and during hypercapnia to assess CVR. Thirty-eight parameters of blood cellular elements, microvesicles, and cell-cell interactions measured in venous blood were assessed for association with CVR using principal component analysis. Middle cerebral artery velocity was lower in the preeclampsia compared

SUBMITTER: Barnes JN 

PROVIDER: S-EPMC5730492 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature