SCARF-1 promotes adhesion of CD4⁺ T cells to human hepatic sinusoidal endothelium under conditions of shear stress.

ABSTRACT: Liver-resident cells are constantly exposed to gut-derived antigens via portal blood and, as a consequence, they express a unique repertoire of scavenger receptors. Whilst there is increasing evidence that the gut contributes to chronic inflammatory liver disease, the role of scavenger receptors in regulating liver inflammation remains limited. Here, we describe for the first time the expression of scavenger receptor class F, member 1 (SCARF-1) on hepatic sinusoidal endothelial cells (HSEC). We report that SCARF-1 shows a highly localised expression pattern and co-localised with endothelial markers on sinusoidal endothelium. Analysis of chronically inflamed liver tissue demonstrated accumulation of SCARF-1 at sites of CD4⁺ T cell aggregation. We then studied the regulation and f

SUBMITTER: Patten DA 

PROVIDER: S-EPMC5730566 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature