The celecoxib derivatives AR-12 and AR-14 induce autophagy and clear prion-infected cells from prions.

ABSTRACT: Prion diseases are fatal infectious neurodegenerative disorders that affect both humans and animals. The autocatalytic conversion of the cellular prion protein (PrP^C) into the pathologic isoform PrP^Sc is a key feature in prion pathogenesis. AR-12 is an IND-approved derivative of celecoxib that demonstrated preclinical activity against several microbial diseases. Recently, AR-12 has been shown to facilitate clearance of misfolded proteins. The latter proposes AR-12 to be a potential therapeutic agent for neurodegenerative disorders. In this study, we investigated the role of AR-12 and its derivatives in controlling prion infection. We tested AR-12 in prion infected neuronal and non-neuronal cell lines. Immunoblotting and confocal microscopy results showed that AR-12 an

SUBMITTER: Abdulrahman BA 

PROVIDER: S-EPMC5730578 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature