Big Data and Genome Editing Technology: A New Paradigm of Cardiovascular Genomics.

ABSTRACT: Opinion Statements: Cardiovascular diseases (CVDs) encompass a range of conditions extending from congenital heart disease to acute coronary syndrome most of which are heterogenous in nature and some of them are multiple genetic loci. However, the pathogenesis of most CVDs remains incompletely understood. The advance in genome-editing technologies, an engineering process of DNA sequences at precise genomic locations, has enabled a new paradigm that human genome can be precisely modified to achieve a therapeutic effect. Genome-editing includes the correction of genetic variants that cause disease, the addition of therapeutic genes to specific sites in the genomic locations, and the removal of deleterious genes or genome sequences. Site-specific genome engineering can be used as nucleases (k

SUBMITTER: Krittanawong C 

PROVIDER: S-EPMC5730963 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature