Blood pressure and the risk of chronic kidney disease progression using multistate marginal structural models in the CRIC Study.

ABSTRACT: In patients with chronic kidney disease (CKD), clinical interest often centers on determining treatments and exposures that are causally related to renal progression. Analyses of longitudinal clinical data in this population are often complicated by clinical competing events, such as end-stage renal disease (ESRD) and death, and time-dependent confounding, where patient factors that are predictive of later exposures and outcomes are affected by past exposures. We developed multistate marginal structural models (MS-MSMs) to assess the effect of time-varying systolic blood pressure on disease progression in subjects with CKD. The multistate nature of the model allows us to jointly model disease progression characterized by changes in the estimated glomerular filtration rate (eGFR), the onset

SUBMITTER: Stephens-Shields AJ 

PROVIDER: S-EPMC5730991 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature