DNA and RNA-sequence based GWAS highlights membrane-transport genes as key modulators of milk lactose content.

ABSTRACT:

Background

Lactose provides an easily-digested energy source for neonates, and is the primary carbohydrate in milk in most species. Bovine lactose is also a key component of many human food products. However, compared to analyses of other milk components, the genetic control of lactose has been little studied. Here we present the first GWAS focussed on analysis of milk lactose traits.

Results

Using a discovery population of 12,000 taurine dairy cattle, we detail 27 QTL for lactose concentration and yield, and subsequently validate the effects of 26 of these loci in a distinct population of 18,000 cows. We next present data implicating causative genes and variants for these QTL. Fine mapping of these regions using imputed, whole genome sequence-resolution genotypes reveals pr

SUBMITTER: Lopdell TJ 

PROVIDER: S-EPMC5731188 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature