Prognostic significance of RBP2-H1 variant of JARID1B in melanoma.

ABSTRACT:

Background

Histone demethylase JARID1B plays several context dependent roles in epigenetic regulation of cellular differentiation in normal development and is highly expressed in multiple human cancers. The protein is a strong transcriptional repressor capable of downregulating numerous genes. There are three splicing isoforms of JARID1B, however the links between the protein structure and function are not clear. The expression pattern of JARID1B in human melanoma seems to be different from observed in other cancers. Moreover, up to now no data on the impact of JARID1B expression in cutaneous melanoma on the patients' prognosis have been reported.

Methods

We investigated immunohistochemically the association of intratumoral expression of total JARID1B protein and its RBP2-H1

SUBMITTER: Kuzbicki L 

PROVIDER: S-EPMC5731204 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature