Tetrahydrocannabinolic acid is a potent PPARγ agonist with neuroprotective activity.

ABSTRACT:

Background and purpose

Phytocannabinoids are produced in Cannabis sativa L. in acidic form and are decarboxylated upon heating, processing and storage. While the biological effects of decarboxylated cannabinoids such as Δ⁹ -tetrahydrocannabinol have been extensively investigated, the bioactivity of Δ⁹ -tetahydrocannabinol acid (Δ⁹ -THCA) is largely unknown, despite its occurrence in different Cannabis preparations. Here we have assessed possible neuroprotective actions of Δ⁹ -THCA through modulation of PPARγ pathways.

Experimental approach

The effects of six phytocannabinoids on PPARγ binding and transcriptional activity were investigated. The effect of Δ⁹ -THCA on mitochondrial biogenesis and PPARγ coactivator 1-α expre

SUBMITTER: Nadal X 

PROVIDER: S-EPMC5731255 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature