DNA methylation changes measured in pre-diagnostic peripheral blood samples are associated with smoking and lung cancer risk.

ABSTRACT: DNA methylation changes are associated with cigarette smoking. We used the Illumina Infinium HumanMethylation450 array to determine whether methylation in DNA from pre-diagnostic, peripheral blood samples is associated with lung cancer risk. We used a case-control study nested within the EPIC-Italy cohort and a study within the MCCS cohort as discovery sets (a total of 552 case-control pairs). We validated the top signals in 429 case-control pairs from another 3 studies. We identified six CpGs for which hypomethylation was associated with lung cancer risk: cg05575921 in the AHRR gene (p-value_pooled  = 4 × 10^-17 ), cg03636183 in the F2RL3 gene (p-value_pooled  = 2 × 10 ^{- 13} ), cg21566642 and cg05951221 in 2q37.1 (p-value_pooled  = 7 × 10<

SUBMITTER: Baglietto L 

PROVIDER: S-EPMC5731426 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature