Cancer risk in cutaneous lupus erythematosus: a population-based cohort study.

ABSTRACT:

Objective

Immune dysregulation associated with chronic autoimmune diseases, such as SLE, has been associated with increased cancer risk. It is unclear whether isolated cutaneous lupus erythematosus (CLE) modifies cancer risk. We estimated the cumulative incidence of cancer in a population-based CLE cohort and compared the risk with a matched non-CLE cohort.

Methods

All incident cases of CLE in Olmsted County, MN, USA between 1965 and 2005 were identified and followed to December 2013. Estimates for the cumulative incidence of any cancer and skin cancer in patients with CLE were derived and compared with an age-, sex- and calendar-year-matched non-CLE cohort using Cox models.

Results

There were a total of 155 patients with CLE [age at diagnosis, 48 (sd 16) years; 65% f

SUBMITTER: Singh AG 

PROVIDER: S-EPMC5731492 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature