Seasonal Influenza Vaccination of Children Induces Humoral and Cell-Mediated Immunity Beyond the Current Season: Cross-reactivity With Past and Future Strains.

ABSTRACT:

Background

Influenza viruses gradually accumulate point mutations, reducing the effectiveness of prior immune protection.

Methods

Children aged 9-14 years received 2010-2011 trivalent inactivated influenza vaccine (TIV). Vaccination history, hemagglutination-inhibition (HI) titers, and cell-mediated immune responses were assessed to investigate the cross-reactivity with past and future influenza virus strains.

Results

2010-2011 TIV induced significant T-cell responses and HI titers of ≥160, with a fold-rise of ≥4 and titers of ≥100 maintained for >7 months in the majority of children. Pre-existing memory B cells in these children differentiated quickly to antibody-secreting cells to the new vaccine antigens. Children vaccinated in the previous year maintained high HI

SUBMITTER: Reber AJ 

PROVIDER: S-EPMC5731644 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature