αII-spectrin in T cells is involved in the regulation of cell-cell contact leading to immunological synapse formation?

ABSTRACT: T-lymphocyte activation after antigen presentation to the T-Cell Receptor (TCR) is a critical step in the development of proper immune responses to infection and inflammation. This dynamic process involves reorganization of the actin cytoskeleton and signaling molecules at the cell membrane, leading to the formation of the Immunological Synapse (IS). The mechanisms regulating the formation of the IS are not completely understood. Nonerythroid spectrin is a membrane skeletal protein involved in the regulation of many cellular processes, including cell adhesion, signaling and actin cytoskeleton remodeling. However, the role of spectrin in IS formation has not been explored. We used molecular, imaging and cellular approaches to show that nonerythroid αII-spectrin redistributes to the IS durin

SUBMITTER: Meissner JM 

PROVIDER: S-EPMC5731749 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature